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Article

Structural model and functional significance of pH-dependent talin-actin binding for focal adhesion remodeling.

Proceedings of the National Academy of Sciences of the United States of America - 23 Sept 2008

Srivastava J, Barreiro G, Groscurth S, Gingras A R, Goult B T, Critchley D R, Kelly M J S, Jacobson M P, Barber D L

Abstract excerpt

Actin filament binding by the focal adhesion (FA)-associated protein talin stabilizes cell-substrate adhesions and is thought to be rate-limiting in cell migration. Although F-actin binding by talin is known to be pH-sensitive in vitro, with lower affinity at higher pH, the functional significance of this pH dependence is unknown. Because increased intracellular pH (pH(i)) promotes cell migration and is a...

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Identifiers

PMID: 18780792
DOI: 10.1073/pnas.0805163105
PMCID: PMC2532973

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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