Article
Uncoupling of neuroinflammation from axonal degeneration in mice lacking the myelin protein tetraspanin-2.
Glia - 1 Nov 2013
de Monasterio-Schrader Patricia, Patzig Julia, Möbius Wiebke, Barrette Benoit, Wagner Tadzio L, Kusch Kathrin, Edgar Julia M, Brophy Peter J, Werner Hauke B
Abstract excerpt
Deficiency of the major constituent of central nervous system (CNS) myelin, proteolipid protein (PLP), causes axonal pathology in spastic paraplegia type-2 patients and in Plp1(null) -mice but is compatible with almost normal myelination. These observations led us to speculate that PLP's role in myelination may be partly compensated for by other tetraspan proteins. Here, we demonstrate that the abundance of the...
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