Article

Conservation and divergence of myelin proteome and oligodendrocyte transcriptome profiles between humans and mice

2022-01-19

Abstract excerpt

Human myelin disorders are commonly studied in mouse models. Since both clades evolutionarily diverged approximately 85 million years ago, it is critical to know to what extent the myelin protein composition has remained similar. Here we use quantitative proteomics to analyze myelin purified from human white matter and find that the relative abundance of the structural myelin proteins PLP, MBP, CNP and SEPTIN8 cor...

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Literature Corpus work: 49d084e8-b13b-5ba2-b2d3-394537646051
DOI: 10.1101/2022.01.17.476643

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