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Article

Peripheral myelin protein 22 is in complex with alpha6beta4 integrin, and its absence alters the Schwann cell basal lamina.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 25 Jan 2006

Amici Stephanie A, Dunn William A, Murphy Andrew J, Adams Niels C, Gale Nicholas W, Valenzuela David M, Yancopoulos George D, Notterpek Lucia

Abstract excerpt

Peripheral myelin protein 22 (PMP22) is a tetraspan membrane glycoprotein, the misexpression of which is associated with hereditary demyelinating neuropathies. Myelinating Schwann cells (SCs) produce the highest levels of PMP22, yet the function of the protein in peripheral nerve biology is unresolved. To investigate the potential roles of PMP22, we engineered a novel knock-out (-/-) mouse line by replacing the...

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Identifiers

PMID: 16436605
DOI: 10.1523/JNEUROSCI.2618-05.2006
PMCID: PMC6674566

Genes

PMP22

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Peripheral myelin protein 22 is in complex with alpha6beta4 integrin, and its absence alters the Schwann cell basal lamina.PMID 16436605Read ↗

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