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Article

Growth properties and tumorigenesis of MCF-7 cells transfected with isogenic mutants of rasH.

Cancer research - 1 Jan 1990

Sommers C L, Papageorge A, Wilding G, Gelmann E P

Abstract excerpt

MCF-7 human breast cancer cells are estrogen dependent for maximal in vitro growth and for tumor formation in nude mice, thus providing a useful model system to study mammary tumorigenesis. A clone of MCF-7 cells transfected with the v-rasH oncogene has been shown to form tumors in the absence of...

Topics

Animals
Breast Neoplasms
Cell Division
Cell Line
Cells, Cultured
Female
Genes, ras
Harvey murine sarcoma virus
Humans
Mice
Mice, Nude
Mutation
Neoplasm Transplantation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plasmids

Proto-Oncogene Proteins

Proto-Oncogene Proteins p21(ras)

Transfection

Transplantation, Heterologous

Source

Identifiers

PMID: 2403419

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2403419-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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