Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Growth properties and tumorigenesis of MCF-7 cells transfected with isogenic mutants of rasH.

Cancer research - 1 Jan 1990

Sommers C L, Papageorge A, Wilding G, Gelmann E P

Abstract excerpt

MCF-7 human breast cancer cells are estrogen dependent for maximal in vitro growth and for tumor formation in nude mice, thus providing a useful model system to study mammary tumorigenesis. A clone of MCF-7 cells transfected with the v-rasH oncogene has been shown to form tumors in the absence of estradiol [Kasid et al., 1985, Science (Wash. DC), 228:725-728]. To extend this observation to more clones of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Plasmids
Share to Cell Division
Share to Cell Line

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cells, Cultured

Share to Genes, ras

Share to Mutation

Share to Transfection

Source

Identifiers

PMID: 2403419

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Growth properties and tumorigenesis of MCF-7 cells transfected with isogenic mutants of rasH.PMID 2403419Read ↗

Human breast cancer progression can be regulated by dominant trans-acting factors in somatic cell hybridization studies.Semantic proximity Read ↗

Anti-oncogenic activity of signalling-defective epidermal growth factor receptor mutants.Semantic proximity Read ↗

Progression of MCF-7 breast cancer cells to antiestrogen-resistant phenotype is accompanied by elevated levels of AP-1 DNA-binding activity.Semantic proximity Read ↗

Altered response of a human squamous cell carcinoma cell line to 1, 25-dihydroxyvitamin D(3) after transfer of a normal chromosome 11.Semantic proximity Read ↗

Step-wise progression in human skin carcinogenesis in vitro involves mutational inactivation of p53, rasH oncogene activation and additional chromosome loss.Semantic proximity Read ↗

Role of the Ha-ras (RasH) oncogene in mediating progression of the tumor cell phenotype (review).Semantic proximity Read ↗

The estrogen receptor from a tamoxifen stimulated MCF-7 tumor variant contains a point mutation in the ligand binding domain.Semantic proximity Read ↗

Human breast carcinoma desmoplasia is PDGF initiated.Semantic proximity Read ↗

v-rasH expression confers hormone-independent in vitro growth to LNCaP prostate carcinoma cells.Semantic proximity Read ↗

Growth factor requirement, oncogene expression and TP53 mutations of a tumorigenic and a non-tumorigenic subline of the human breast carcinoma cell line, HMT-3909.Semantic proximity Read ↗

Adenovirus type 9 E4 open reading frame 1 encodes a transforming protein required for the production of mammary tumors in ratsSemantic proximity Read ↗

p53 mutation and tamoxifen resistance in breast cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.