Article
The estrogen receptor from a tamoxifen stimulated MCF-7 tumor variant contains a point mutation in the ligand binding domain.
Breast cancer research and treatment - 1 Jan 1994
Wolf D M, Jordan V C
Abstract excerpt
The nonsteroidal antiestrogen tamoxifen (TAM) is the most commonly used endocrine treatment for all stages of breast cancer in both pre- and postmenopausal women. However, the development of resistance to the drug is common, as most patients treated with TAM eventually experience a recurrence of...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Binding Sites
- Breast Neoplasms
- Cell Division
- Cloning, Molecular
- DNA Primers
- Female
- Genetic Variation
- Humans
- Mice
- Mice, Nude
- Molecular Sequence Data
- Point Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Postmenopause