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Adenovirus type 9 E4 open reading frame 1 encodes a transforming protein required for the production of mammary tumors in rats

1 Jun 1994

Abstract excerpt

The E4 region of human adenovirus type 9 (Ad9) transforms established rat embryo fibroblasts and encodes an essential determinant for the production of estrogen-dependent mammary tumors in rats. Testing of the seven Ad9 E4 open reading frames (ORFs) individually for transformation of the established rat embryo fibroblast cell line CREF indicated that only Ad9 E4 ORF1 possessed a significant ability to generate...

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Identifiers

PMID: 8189528
DOI: 10.1128/jvi.68.6.3917-3924.1994

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