Article
Human breast carcinoma desmoplasia is PDGF initiated.
Oncogene - 7 Sept 2000
Shao Z M, Nguyen M, Barsky S H
Abstract excerpt
The desmoplastic response to human breast carcinoma is a host myofibroblast-mediated collagenous response exhibiting synergistic effects on tumor progression. Although many paracrine interactions between breast carcinoma cells and myofibroblasts have been characterized, the event(s) which initiate desmoplasia have remained undefined. Our studies utilized c-rasH transfected MCF-7 cells which overexpress ras p2l...
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