Article
Progression of MCF-7 breast cancer cells to antiestrogen-resistant phenotype is accompanied by elevated levels of AP-1 DNA-binding activity.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Mar 1996
Dumont J A, Bitonti A J, Wallace C D, Baumann R J, Cashman E A, Cross-Doersen D E
Abstract excerpt
We have isolated a variant of the MCF-7 human breast tumor that is characterized by a hormone-independent, yet hormone-responsive, phenotype. This tumor, designated MCF-WES, was derived from MCF-7 tumor cells implanted in the mammary fat pad of a nude mouse in the absence of estradiol supplementa...
Topics
- Animals
- Breast Neoplasms
- Cell Division
- DNA, Neoplasm
- Drug Resistance, Neoplasm
- Estradiol
- Estrogen Antagonists
- Fulvestrant
- Gelatinases
- Humans
- Mice
- Mice, Nude
- Phenotype
- Protein Binding
- RNA, Messenger
- Receptors, Estrogen
- Receptors, Progesterone
- Tamoxifen