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Article

Role of the Ha-ras (RasH) oncogene in mediating progression of the tumor cell phenotype (review).

Anticancer research - 1 Jan 2000

Boylan J F, Jackson J, Steiner M R, Shih T Y, Duigou G J, Roszman T, Fisher P B, Zimmer S G

Abstract excerpt

Recent experimental evidence indicates that the c-Ha-ras (rasH) oncogene may be causally involved in the etiology and evolution of specific human neoplasms. In addition, cultured cells transformed by the rasH oncogene can induce both a tumorigenic and a metastatic phenotype when expressed in appropriate cultured cells. To begin to define the molecular and biochemical mechanism(s) by which the rasH oncogene induce...

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PMID: 2195986

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