Human breast cancer progression can be regulated by dominant trans-acting factors in somatic cell hybridization studies.

Article

Human breast cancer progression can be regulated by dominant trans-acting factors in somatic cell hybridization studies.

Cancer research - 1 Aug 1996

Safarians S, Sternlicht M D, Yamanishi D T, Love S M, Barsky S H

Abstract excerpt

Human breast cancer is often characterized by a progression to an ER (estrogen receptor)-negative, estrogen-independent, antiestrogen-resistant, EGFR (epidermal growth factor receptor)-positive, and highly metastatic phenotype. The molecular and biochemical mechanisms behind this progression are...

Topics

Animals
Breast Neoplasms
Cell Fusion
Disease Progression
ErbB Receptors
Female
Humans
Hybrid Cells
Mice
Mice, Inbred BALB C
Mice, Nude
Mice, SCID
Phenotype
Receptors, Estrogen
Transfection

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