v-rasH expression confers hormone-independent in vitro growth to LNCaP prostate carcinoma cells.

doi:10.1210/mend-5-2-209

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Article

v-rasH expression confers hormone-independent in vitro growth to LNCaP prostate carcinoma cells.

Molecular endocrinology (Baltimore, Md.) - 1 Feb 1991

Voeller H J, Wilding G, Gelmann E P

Abstract excerpt

The LNCaP human prostate cancer cell line is dependent on androgen for in vitro growth. To discover genes that may be responsible for progression of prostate cancer from hormone dependence to hormone independence, we transfected LNCaP cells with expression vectors that contained either the v-rasH or c-rasH gene under the control of the cadmium (Cd2+)-inducible human metallothionein-IIA promoter. Numerous...

Topics

Animals
Cadmium
Cell Division
Dihydrotestosterone
Gene Expression
Genes, ras
Humans
Male
Metallothionein
Mice
Mice, Nude
Neoplasm Transplantation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oncogene Protein p21(ras)

Phenotype

Promoter Regions, Genetic

Prostatic Neoplasms

RNA, Messenger

Transfection

Source

Open in PubMed

Identifiers

PMID: 2038342
DOI: 10.1210/mend-5-2-209

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2038342-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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