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Article

p53 mutation and tamoxifen resistance in breast cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 1995

Elledge R M, Lock-Lim S, Allred D C, Hilsenbeck S G, Cordner L

Abstract excerpt

A substantial portion of patients with estrogen receptor-positive breast cancer fail to respond to estrogen depletion or to the antiestrogen tamoxifen. The molecular changes that lead to tamoxifen resistance and estrogen-independent growth are unknown. To test the hypothesis that a p53 mutation could result in tamoxifen resistance and estrogen-independent growth, the MCF-7 cell line was transfected with p53 cDNA...

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PMID: 9815913

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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