Article
Mapping of Mcs30, a new mammary carcinoma susceptibility quantitative trait locus (QTL30) on rat chromosome 12: identification of fry as a candidate Mcs gene.
PloS one - 1 Jan 2013
Ren Xuefeng, Graham Jessica C, Jing Lichen, Mikheev Andrei M, Gao Yuan, Lew Jenny Pan, Xie Hong, Kim Andrea S, Shang Xiuling, Friedman Cynthia, Vail Graham, Fang Ming Zhu, Bromberg Yana, Zarbl Helmut
Abstract excerpt
Rat strains differ dramatically in their susceptibility to mammary carcinogenesis. On the assumption that susceptibility genes are conserved across mammalian species and hence inform human carcinogenesis, numerous investigators have used genetic linkage studies in rats to identify genes responsible for differential susceptibility to carcinogenesis. Using a genetic backcross between the resistant Copenhagen (Cop)...
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