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Article

Mcs5c: a mammary carcinoma susceptibility locus located in a gene desert that associates with tenascin C expression.

Cancer prevention research (Philadelphia, Pa.) - 1 Jan 2011

Veillet Adeline L, Haag Jill D, Remfert Jane L, Meilahn Amanda L, Samuelson David J, Gould Michael N

Abstract excerpt

Genetic factors have been estimated to account for at least 30% of a woman's risk to develop breast cancer. We have developed a rat model using Wistar Furth (WF) and Wistar Kyoto (WKy) strains to genetically identify mammary cancer susceptibility loci. The WKy allele of the mammary carcinogenesis susceptibility locus Mcs5c, was previously shown to reduce carcinoma multiplicity after...

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Identifiers

PMID: 21205740
DOI: 10.1158/1940-6207.CAPR-10-0187
PMCID: PMC3447625

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mcs5c: a mammary carcinoma susceptibility locus located in a gene desert that associates with tenascin C expression.PMID 21205740Read ↗

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Rat Mcs5a is a compound quantitative trait locus with orthologous human loci that associate with breast cancer risk.Semantic proximity Read ↗

The non-protein coding breast cancer susceptibility locus Mcs5a acts in a non-mammary cell-autonomous fashion through the immune system and modulates T-cell homeostasis and functions.Semantic proximity Read ↗

The Mcs7 quantitative trait locus is associated with an increased susceptibility to mammary cancer in congenic rats and an allele-specific imbalance.Semantic proximity Read ↗

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Physical Confirmation and Comparative Genomics of the Rat Mammary carcinoma susceptibility 3 Quantitative Trait Locus.Semantic proximity Read ↗

The gene desert mammary carcinoma susceptibility locus Mcs1a regulates Nr2f1 modifying mammary epithelial cell differentiation and proliferation.Semantic proximity Read ↗

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