Article
Rat Mcs1b is concordant to the genome-wide association-identified breast cancer risk locus at human 5q11.2 and MIER3 is a candidate cancer susceptibility gene.
Cancer research - 15 Nov 2012
denDekker Aaron D, Xu Xin, Vaughn M Derek, Puckett Aaron H, Gardner Louis L, Lambring Courtney J, Deschenes Lucas, Samuelson David J
Abstract excerpt
Low-penetrance alleles associated with breast cancer risk have been identified in population-based studies. Most risk loci contain either no or multiple potential candidate genes. Rat mammary carcinoma susceptibility 1b (Mcs1b) is a quantitative trait locus on RN02 that confers decreased susceptibility when Copenhagen (COP)-resistant alleles are introgressed into a Wistar Furth (WF)-susceptible genome. Five...
Topics
- Alleles
- Animals
- Animals, Congenic
- Body Weight
- Breast Neoplasms
- Cell Nucleus
- Chromosome Mapping
- Chromosomes, Human, Pair 5
- Female
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Mammary Neoplasms, Experimental