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Article

Identification and functional analysis of Rattus norvegicus Mammary carcinoma susceptibility 1b (Mcs1b) nominated variants.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Dec 2025

Sanders Jennifer, Kalbfleisch Theodore S, Le Sasha, Xu Xin, Cummins Timothy D, Powell David W, Samuelson David J

Abstract excerpt

Rattus norvegicus (a.k.a. laboratory rat or Brown Rat) Mammary carcinoma susceptibility 1b (Mcs1b) is a concordant ortholog of a female breast cancer risk allele at human 5q11.2. Previously, Mcs1b was delimited to a 1.8 Mb interval of RNO2 and Map3k1 along with Mier3 were determined to be Mcs1b-nonminated genes. This conclusion was based on shared synteny with human 5q11.2 and differential gene expression between...

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PMID: 40973823
DOI: 10.1007/s00335-025-10157-5

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