Rat Mcs5a is a compound quantitative trait locus with orthologous human loci that associate with breast cancer risk.

doi:10.1073/pnas.0701687104

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Article

Rat Mcs5a is a compound quantitative trait locus with orthologous human loci that associate with breast cancer risk.

Proceedings of the National Academy of Sciences of the United States of America - 10 Apr 2007

Samuelson David J, Hesselson Stephanie E, Aperavich Beth A, Zan Yunhong, Haag Jill D, Trentham-Dietz Amy, Hampton John M, Mau Bob, Chen Kai-Shun, Baynes Caroline, Khaw Kay-Tee, Luben Robert, Perkins Barbara, Shah Mitul, Pharoah Paul D, Dunning Alison M, Easton Doug F, Ponder Bruce A, Gould Michael N

Abstract excerpt

Breast cancer risk is a polygenic trait. To identify breast cancer modifier alleles that have a high population frequency and low penetrance we used a comparative genomics approach. Quantitative trait loci (QTL) were initially identified by linkage analysis in a rat mammary carcinogenesis model followed by verification in congenic rats carrying the specific QTL allele under study. The Mcs5a locus was identified...

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PMID: 17404222
DOI: 10.1073/pnas.0701687104
PMCID: PMC1847458

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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