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Article

Physical evidence of Mcs5, a QTL controlling mammary carcinoma susceptibility, in congenic rats.

Carcinogenesis - 1 Sept 2003

Samuelson David J, Haag Jill D, Lan Hong, Monson Dinelli M, Shultz Millicent A, Kolman Bradley D, Gould Michael N

Abstract excerpt

Genetic susceptibility to breast cancer is influenced by high- and low-penetrance genes. The low-penetrance genes contributing to increased and decreased risk likely exist at appreciable frequencies in the human population. To identify high-frequency, low-penetrance modifier genes, we are using a rat genetic model. Eight quantitative trait loci, named mammary carcinoma susceptibility (Mcs) loci, have been...

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Source

Identifiers

PMID: 12844486
DOI: 10.1093/carcin/bgg112

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Physical evidence of Mcs5, a QTL controlling mammary carcinoma susceptibility, in congenic rats.PMID 12844486Read ↗

Fine mapping reveals multiple loci and a possible epistatic interaction within the mammary carcinoma susceptibility quantitative trait locus, Mcs5.Semantic proximity Read ↗

The Mcs7 quantitative trait locus is associated with an increased susceptibility to mammary cancer in congenic rats and an allele-specific imbalance.Semantic proximity Read ↗

Genetic loci controlling breast cancer susceptibility in the Wistar-Kyoto rat.Semantic proximity Read ↗

Mcs5c: a mammary carcinoma susceptibility locus located in a gene desert that associates with tenascin C expression.Semantic proximity Read ↗

Rat Mcs5a is a compound quantitative trait locus with orthologous human loci that associate with breast cancer risk.Semantic proximity Read ↗

Genetic identification of multiple loci that control breast cancer susceptibility in the rat.Semantic proximity Read ↗

Rat Mammary carcinoma susceptibility 3 (Mcs3) pleiotropy, socioenvironmental interaction, and comparative genomics with orthologous human 15q25.1-25.2.Semantic proximity Read ↗

Rat Mcs1b is concordant to the genome-wide association-identified breast cancer risk locus at human 5q11.2 and MIER3 is a candidate cancer susceptibility gene.Semantic proximity Read ↗

Physical Confirmation and Comparative Genomics of the Rat Mammary carcinoma susceptibility 3 Quantitative Trait Locus.Semantic proximity Read ↗

Congenic rats reveal three independent Copenhagen alleles within the Mcs1 quantitative trait locus that confer resistance to mammary cancer.Semantic proximity Read ↗

Isolation of two regions on rat chromosomes 5 and 18 affecting mammary cancer susceptibility.Semantic proximity Read ↗

The non-protein coding breast cancer susceptibility locus Mcs5a acts in a non-mammary cell-autonomous fashion through the immune system and modulates T-cell homeostasis and functions.Semantic proximity Read ↗

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