Article
The gene desert mammary carcinoma susceptibility locus Mcs1a regulates Nr2f1 modifying mammary epithelial cell differentiation and proliferation.
PLoS genetics - 1 Jun 2013
Smits Bart M G, Haag Jill D, Rissman Anna I, Sharma Deepak, Tran Ann, Schoenborn Alexi A, Baird Rachael C, Peiffer Dan S, Leinweber David Q, Muelbl Matthew J, Meilahn Amanda L, Eichelberg Mark R, Leng Ning, Kendziorski Christina, John Manorama C, Powers Patricia A, Alexander Caroline M, Gould Michael N
Abstract excerpt
Genome-wide association studies have revealed that many low-penetrance breast cancer susceptibility loci are located in non-protein coding genomic regions; however, few have been characterized. In a comparative genetics approach to model such loci in a rat breast cancer model, we previously identified the mammary carcinoma susceptibility locus Mcs1a. We now localize Mcs1a to a critical interval (277 Kb) within a...
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