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Fine mapping reveals multiple loci and a possible epistatic interaction within the mammary carcinoma susceptibility quantitative trait locus, Mcs5.

Cancer research - 1 Nov 2005

Samuelson David J, Aperavich Beth A, Haag Jill D, Gould Michael N

Abstract excerpt

To identify high-frequency, low-penetrance breast cancer modifier genes, we have developed a rat genetic model that uses the Wistar-Kyoto (WKy) inbred strain, resistant to developing 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis, as a congenic donor and the susceptible Wistar-Furth (WF) strain as the recipient. Here, data from congenic rat lines containing smaller WKy genomic intervals of the Mcs5...

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Identifiers

PMID: 16266982
DOI: 10.1158/0008-5472.CAN-05-1498

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Fine mapping reveals multiple loci and a possible epistatic interaction within the mammary carcinoma susceptibility quantitative trait locus, Mcs5.PMID 16266982Read ↗

Physical evidence of Mcs5, a QTL controlling mammary carcinoma susceptibility, in congenic rats.Semantic proximity Read ↗

Mcs5c: a mammary carcinoma susceptibility locus located in a gene desert that associates with tenascin C expression.Semantic proximity Read ↗

Rat Mcs5a is a compound quantitative trait locus with orthologous human loci that associate with breast cancer risk.Semantic proximity Read ↗

Genetic loci controlling breast cancer susceptibility in the Wistar-Kyoto rat.Semantic proximity Read ↗

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The non-protein coding breast cancer susceptibility locus Mcs5a acts in a non-mammary cell-autonomous fashion through the immune system and modulates T-cell homeostasis and functions.Semantic proximity Read ↗

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