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Sirtuin-3 (SIRT3) and the Hallmarks of Cancer

1 Mar 2013

Abstract excerpt

Sirtuins (SIRT1-SIRT7), the mammalian homologs of the silent information regulator 2 (Sir2) in Saccharomyces cerevisiae, have been a major focus of study in the scientific community this past decade because of their emerging role in cancer biology and other age-related diseases. Emerging functions for this unique family of enzymes include roles in genomic stability, angiogenesis, metabolism, and anoikis. Here, we...

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PMID: 24020007
DOI: 10.1177/1947601913486351

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