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Sirtuin 3: A Janus face in cancer (Review)

10 Nov 2016

Abstract excerpt

The NAD-dependent protein deacetylase sirtuin 3 (SIRT3) is an enzyme localized primarily in the mitochondrion, where it modulates cellular functions such as nutrient metabolism, ATP balance, antioxidant machinery, and other mechanisms fundamental to mitochondria. SIRT3 is closely associated with the pathogenesis of diverse disorders. In particular, it plays a dual role in the development and progression of...

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PMID: 27840909
DOI: 10.3892/ijo.2016.3767

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