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Article

The Roles of Sirtuin Family Proteins in Cancer Progression

5 Dec 2019

Abstract excerpt

Sirtuin family members are characterized by either mono-ADP-ribosyltransferase or deacylase activity and are linked to various cancer-related biological pathways as regulators of transcriptional progression. Sirtuins play fundamental roles in carcinogenesis and maintenance of the malignant phenotype, mainly participating in cancer cell viability, apoptosis, metastasis, and tumorigenesis. Although sirtuin family...

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PMID: 31817470
DOI: 10.3390/cancers11121949

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