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Targeting sirtuins for cancer therapy: epigenetics modifications and beyond

1 Jan 2024

Abstract excerpt

)-dependent histone deacetylases, which are important epigenetic enzymes consisting of seven family members (SIRT1-7). Of note, SIRT1 and SIRT2 are distributed in the nucleus and cytoplasm, while SIRT3, SIRT4 and SIRT5 are localized in the mitochondria. SIRT6 and SIRT7 are distributed in the nucleus. SIRTs catalyze the deacetylation of various substrate proteins, thereby modulating numerous biological processes,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39479446
DOI: 10.7150/thno.100667

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