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Role of Sirtuins in Maintenance of Genomic Stability: Relevance to Cancer and Healthy Aging

5 Jul 2016

Abstract excerpt

Genomic instability and epigenetic alterations are distinct hallmarks shared by cancer and aging. Sirtuins (SIRTs) are class III histone deacetylases that regulate gene expression in response to cellular metabolic status. SIRTs can modulate chromatin function through direct deacetylation of histones and by promoting altered methylation of histones and DNA, leading to repression of transcription. They can also...

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PMID: 27380140
DOI: 10.1089/dna.2016.3280

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