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Rejuvenating Sirtuins: The Rise of a New Family of Cancer Drug Targets

20 Dec 2012

Abstract excerpt

Sirtuins are a family of NAD+-dependent enzymes that was proposed to control organismal life span about a decade ago. While such role of sirtuins is now debated, mounting evidence involves these enzymes in numerous physiological processes and disease conditions, including metabolism, nutritional behavior, circadian rhythm, but also inflammation and cancer. SIRT1, SIRT2, SIRT3, SIRT6, and SIRT7 have all been...

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PMID: 23016857
DOI: 10.2174/138161213804581954

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