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Article

GSK-3β inhibition preserves naive T cell phenotype in bone marrow reconstituted mice.

Experimental hematology - 1 Dec 2013

Shen Sylvie, Klamer Guy, Xu Ning, O'Brien Tracey A, Dolnikov Alla

Abstract excerpt

Hematopoietic stem cell transplantation (HSCT) is used in the treatment of hematologic and nonhematologic disorders. PostHSCT immunologic reconstitution is a critical component for successful outcome. Pretransplant conditioning impairs thymic function, leading to delayed T cell regeneration. Thymus-independent T cell expansion is associated with defective generation of naive T cells and memory T cell skewing,...

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Source

Identifiers

PMID: 24018603
DOI: 10.1016/j.exphem.2013.08.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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