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Article

Inhibition of Glycogen Synthase Kinase 3β Increases the Proportion and Suppressive Function of CD19+CD24hiCD27+ Breg Cells.

Frontiers in immunology - 1 Jan 2020

Li Jinyang, Gao Ji, Zhou Haoming, Zhou Jinren, Deng Zhenghua, Lu Yunjie, Rao Jianhua, Ji Guwei, Gu Jian, Yang Xinxiang, Xia Yongxiang, Wang Xuehao

Abstract excerpt

CD19+CD24hiCD27+ memory Breg cells exhibit decreased abundance in patients with chronic graft-versus-host disease (cGVHD) after liver transplantation and produce less IL-10 than those from patients without cGVHD and healthy donors. Due to the lack of Breg cells and the difficulty in expanding them in vitro, in mouse models and early human clinical trials, the adoptive transfer of Breg cells to autoimmune diseases...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33343576
DOI: 10.3389/fimmu.2020.603288
PMCID: PMC7746849

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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