Article
Synthetic small molecules that control stem cell fate.
Proceedings of the National Academy of Sciences of the United States of America - 24 Jun 2003
Ding Sheng, Wu Tom Y H, Brinker Achim, Peters Eric C, Hur Wooyoung, Gray Nathanael S, Schultz Peter G
Abstract excerpt
In an attempt to better understand and control the processes that regulate stem cell fate, we have set out to identify small molecules that induce neuronal differentiation in embryonic stem cells (ESCs). A high-throughput phenotypic cell-based screen of kinase-directed combinatorial libraries led to the discovery of TWS119, a 4,6-disubstituted pyrrolopyrimidine that can induce neurogenesis in murine ESCs. The...
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