Article

Wnt/β-catenin regulates alloreactive T cells for the treatment of hematological malignancies

2021-04-12

Abstract excerpt

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is one of the most widely applied forms of adaptive immunotherapy. Both the detrimental graft-versus-host disease (GVHD) and the beneficial graft-versus-leukemia (GVL) effects occurring after allo-HSCT are largely mediated by alloantigen-reactive donor T cells in the graft. Separating GVHD from GVL effects is a formidable challenge, and a greater under...

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Literature Corpus work: 768cba6a-b749-503f-bd75-951e215be91f
DOI: 10.1101/2021.04.12.439538

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