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Urinary TERT promoter mutations as non-invasive biomarkers for the comprehensive detection of urothelial cancer

20 May 2019

Abstract excerpt

BACKGROUND: Recurrent mutations in the promoter of the telomerase reverse transcriptase (TERT) gene (C228T and C250T) detected in tumours and cells shed into urine of urothelial cancer (UC) patients are putative biomarkers for UC detection and monitoring. However, the possibility of detecting these mutations in cell-free circulating DNA (cfDNA) in blood and urine, or DNA from urinary exfoliated cells (cellDNA)...

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Share to Bladder and Urothelial Cancer Treatments
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PMID: 31122840
DOI: 10.1016/j.ebiom.2019.05.004

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