Article
Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros.
Nature immunology - 1 Oct 2013
Schjerven Hilde, McLaughlin Jami, Arenzana Teresita L, Frietze Seth, Cheng Donghui, Wadsworth Sarah E, Lawson Gregory W, Bensinger Steven J, Farnham Peggy J, Witte Owen N, Smale Stephen T
Abstract excerpt
C2H2 zinc fingers are found in several key transcriptional regulators in the immune system. However, these proteins usually contain more fingers than are needed for sequence-specific DNA binding, which suggests that different fingers regulate different genes and functions. Here we found that mice lacking finger 1 or finger 4 of Ikaros exhibited distinct subsets of the hematological defects of Ikaros-null mice....
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