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Multifaceted roles of IKZF1 gene, perspectives from bench to bedside

24 Jun 2024

Abstract excerpt

The IKZF1 gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The protein product, IKAROS, had been proved to regulate lymphopoiesis. Subsequent mouse model studies have further confirmed its regulating role in lymphopoiesis as well as in hematopoiesis; besides, it associates with immune function, certain immune disorders like...

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PMID: 38978740
DOI: 10.3389/fonc.2024.1383419

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