Article
IKZF1: a critical role in the pathogenesis of systemic lupus erythematosus?
Modern rheumatology - 1 Mar 2013
Hu Su-juan, Wen Lei-lei, Hu Xin, Yin Xian-yong, Cui Yong, Yang Sen, Zhang Xue-jun
Abstract excerpt
Ikaros family zinc finger 1, encoded by IKZF1, are lymphoid-restricted zinc finger transcription factors that share common N-terminal Kruppel-like zinc finger DNA-binding domain. IKZF1 play multiple important roles on regulators of lymphocyte differentiation and hematological tumor suppressor. Our genome-wide association (GWA) studies in systemic lupus erythematosus (SLE) independently identified genetic variants...
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