Article

Cross-cohort analysis of expression and splicing quantitative trait loci in TOPMed

2025-02-21

Abstract excerpt

Most genetic variants associated with complex traits and diseases occur in non-coding genomic regions and are hypothesized to regulate gene expression. To understand the genetics underlying gene expression variability, we characterize 14,324 ancestrally diverse RNA-sequencing samples from the NHLBI Trans-Omics for Precision Medicine (TOPMed) program and integrate whole genome sequencing data to perform cis and t...

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Literature Corpus work: 1993c35f-bd75-5427-9b45-b14fef401a21
DOI: 10.1101/2025.02.19.25322561

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