Article
Widespread allele-specific topological domains in the human genome are not confined to imprinted gene clusters.
Genome biology - 3 Mar 2023
Richer Stephen, Tian Yuan, Schoenfelder Stefan, Hurst Laurence, Murrell Adele, Pisignano Giuseppina
Abstract excerpt
BACKGROUND: There is widespread interest in the three-dimensional chromatin conformation of the genome and its impact on gene expression. However, these studies frequently do not consider parent-of-origin differences, such as genomic imprinting, which result in monoallelic expression. In addition, genome-wide allele-specific chromatin conformation associations have not been extensively explored. There are few...
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