Article
The role of MeCP2 in CNS development and function.
Hormones and behavior - 1 Mar 2011
Na Elisa S, Monteggia Lisa M
Abstract excerpt
Rett syndrome is a neurodevelopmental disorder that is a direct consequence of functional mutations in the methyl-CpG-binding protein-2 (MeCP2) gene, which has focused attention on epigenetic mechanisms in neurons. MeCP2 is widely believed to be a transcriptional repressor although it may have additional functions in the CNS. Genetic mouse models that compromise MeCP2 function demonstrate that homeostatic...
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