Homoarginine levels are regulated by L-arginine:glycine amidinotransferase and affect stroke outcome: results from human and murine studies.

doi:10.1161/CIRCULATIONAHA.112.000580

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Article

Homoarginine levels are regulated by L-arginine:glycine amidinotransferase and affect stroke outcome: results from human and murine studies.

Circulation - 24 Sept 2013

Choe Chi-un, Atzler Dorothee, Wild Philipp S, Carter Angela M, Böger Rainer H, Ojeda Francisco, Simova Olga, Stockebrand Malte, Lackner Karl, Nabuurs Christine, Marescau Bart, Streichert Thomas, Müller Christian, Lüneburg Nicole, De Deyn Peter P, Benndorf Ralf A, Baldus Stephan, Gerloff Christian, Blankenberg Stefan, Heerschap Arend, Grant Peter J, Magnus Tim, Zeller Tanja, Isbrandt Dirk, Schwedhelm Edzard

Abstract excerpt

BACKGROUND: Endogenous arginine homologues, including homoarginine, have been identified as novel biomarkers for cardiovascular disease and outcomes. Our studies of human cohorts and a confirmatory murine model associated the arginine homologue homoarginine and its metabolism with stroke pathology and outcome. METHODS AND RESULTS: Increasing homoarginine levels were independently associated with a reduction in...

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PMID: 24004504
DOI: 10.1161/CIRCULATIONAHA.112.000580

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GAMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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