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Article

Dimethylarginine dimethylaminohydrolase-1 transgenic mice are not protected from ischemic stroke.

PloS one - 7 Oct 2009

Leypoldt Frank, Choe Chi-Un, Gelderblom Mathias, von Leitner Eike-Christin, Atzler Dorothee, Schwedhelm Edzard, Gerloff Christian, Sydow Karsten, Böger Rainer H, Magnus Tim

Abstract excerpt

BACKGROUND: Methylated arginines are endogenous analogues of L-arginine, the substrate for nitric oxide (NO) synthase. Asymmetric dimethylarginine (ADMA) interferes with NO formation, causing endothelial dysfunction. ADMA is a predictor of cardiovascular events and mortality in humans. It is eliminated primarily by enzymatic activity of dimethylarginine dimethylaminohydrolase (DDAH). METHODOLOGY/PRINCIPAL...

Topics

Amidohydrolases
Animals
Arginine
Brain
Endothelium, Vascular
Genotype
Infarction, Middle Cerebral Artery
Ischemia
Male
Mice
Mice, Transgenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Biological

Nitric Oxide

Stroke

Source

Open in PubMed Open full text

Identifiers

PMID: 19809508
DOI: 10.1371/journal.pone.0007337
PMCID: PMC2753663

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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