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Article

Muscle phenotype of AGAT- and GAMT-deficient mice after simvastatin exposure.

Amino acids - 1 Jan 2020

Sasani Ali, Hornig Sönke, Grzybowski Ricarda, Cordts Kathrin, Hanff Erik, Tsikas Dimitris, Böger Rainer, Gerloff Christian, Isbrandt Dirk, Neu Axel, Schwedhelm Edzard, Choe Chi-Un

Abstract excerpt

Statin-induced myopathy affects more than 10 million people worldwide. But discontinuation of statin treatment increases mortality and cardiovascular events. Recently, L-arginine:glycine amidinotransferase (AGAT) gene was associated with statin-induced myopathy in two populations, but the causal link is still unclear. AGAT is responsible for the synthesis of L-homoarginine (hArg) and guanidinoacetate (GAA). GAA...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 31853708
DOI: 10.1007/s00726-019-02812-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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