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Article

EGFR transactivates RON to drive oncogenic crosstalk.

eLife - 25 Nov 2021

Franco Nitta Carolina, Green Ellen W, Jhamba Elton D, Keth Justine M, Ortiz-Caraveo Iraís, Grattan Rachel M, Schodt David J, Gibson Aubrey C, Rajput Ashwani, Lidke Keith A, Wilson Bridget S, Steinkamp Mara P, Lidke Diane S

Abstract excerpt

Crosstalk between different receptor tyrosine kinases (RTKs) is thought to drive oncogenic signaling and allow therapeutic escape. EGFR and RON are two such RTKs from different subfamilies, which engage in crosstalk through unknown mechanisms. We combined high-resolution imaging with biochemical and mutational studies to ask how EGFR and RON communicate. EGF stimulation promotes EGFR-dependent phosphorylation of...

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Identifiers

PMID: 34821550
DOI: 10.7554/eLife.63678
PMCID: PMC8654365

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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