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Estrogen and Estrogen Receptor-α-Mediated Transrepression of Bile Salt Export Pump

12 Feb 2015

Abstract excerpt

Among diseases unique to pregnancy, intrahepatic cholestasis of pregnancy is the most prevalent disorder with elevated serum bile acid levels. We have previously shown that estrogen 17β-estradiol (E2) transrepresses bile salt export pump (BSEP) through an interaction between estrogen receptor (ER)-α and farnesoid X receptor (FXR) and transrepression of BSEP by E2/ERα is an etiological contributing factor to...

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PMID: 25675114
DOI: 10.1210/me.2015-1014

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