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Liver receptor homolog 1 transcriptionally regulates human bile salt export pump expression

12 Feb 2008

Abstract excerpt

The metabolic conversion of cholesterol into bile acids in liver is initiated by the rate-limiting cholesterol 7 alpha-hydroxylase (CYP7A1), whereas the bile salt export pump (BSEP) is responsible for the canalicular secretion of bile acids. Liver receptor homolog 1 (LRH-1) is a key transcriptional factor required for the hepatic expression of CYP7A1. We hypothesized that LRH-1 was also involved in the...

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PMID: 18270374
DOI: 10.1194/jlr.m700417-jlr200

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