Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

αKlotho Regulates Age-Associated Vascular Calcification and Lifespan in Zebrafish

1 Sept 2019

Abstract excerpt

The hormone αKlotho regulates lifespan in mice, as knockouts die early of what appears to be accelerated aging due to hyperphosphatemia and soft tissue calcification. In contrast, the overexpression of αKlotho increases lifespan. Given the severe mouse phenotype, we generated zebrafish mutants for αklotho as well as its binding partner fibroblast growth factor-23 (fgf23). Both mutations cause shortened lifespan...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Syndromes and Imprinting
Share to Heterotopic Ossification and Related Conditions
Share to Parathyroid Disorders and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31509740
DOI: 10.1016/j.celrep.2019.08.013

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

αKlotho Regulates Age-Associated Vascular Calcification and Lifespan in ZebrafishPMID 31509740Read ↗

Loss of αklotho causes reduced motor ability and short lifespan in zebrafishSemantic proximity Read ↗

Premature aging in klotho mutant mice: cause or consequence?Semantic proximity Read ↗

Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process.Semantic proximity Read ↗

Calpain 1 inhibitor BDA-410 ameliorates α-klotho-deficiency phenotypes resembling human aging-related syndromes.Semantic proximity Read ↗

Role of Klotho in the Development of Essential Hypertension.Semantic proximity Read ↗

Klotho and aging.Semantic proximity Read ↗

Vascular calcification and osteoporosis--from clinical observation towards molecular understanding.Semantic proximity Read ↗

Klotho: a fundamental regulator of aging.Semantic proximity Read ↗

The Antisenescence Protein Klotho Is Necessary for FGF23-Induced PhosphaturiaSemantic proximity Read ↗

Klotho and the aging process.Semantic proximity Read ↗

The Klotho gene family and the endocrine fibroblast growth factorsSemantic proximity Read ↗

Toward a better understanding of Klotho.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.