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Article

Pharmacological HIF2α inhibition improves VHL disease-associated phenotypes in zebrafish model.

The Journal of clinical investigation - 1 May 2015

Metelo Ana Martins, Noonan Haley R, Li Xiang, Jin Youngnam, Baker Rania, Kamentsky Lee, Zhang Yiyun, van Rooijen Ellen, Shin Jordan, Carpenter Anne E, Yeh Jing-Ruey, Peterson Randall T, Iliopoulos Othon

Abstract excerpt

Patients with a germline mutation in von Hippel-Lindau (VHL) develop renal cell cancers and hypervascular tumors of the brain, adrenal glands, and pancreas as well as erythrocytosis. These phenotypes are driven by aberrant expression of HIF2α, which induces expression of genes involved in cell pr...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25866969
DOI: 10.1172/JCI73665
PMCID: PMC4463187

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25866969-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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