Article
VHL deletion impairs mammary alveologenesis but is not sufficient for mammary tumorigenesis.
The American journal of pathology - 1 May 2010
Seagroves Tiffany N, Peacock Danielle L, Liao Debbie, Schwab Luciana P, Krueger Robin, Handorf Charles R, Haase Volker H, Johnson Randall S
Abstract excerpt
Overexpression of hypoxia inducible factor-1 (HIF-1)alpha, which is common in most solid tumors, correlates with poor prognosis and high metastatic risk in breast cancer patients. Because HIF-1alpha protein stability is tightly controlled by the tumor suppressor von Hippel-Lindau (VHL), deletion of VHL results in constitutive HIF-1alpha expression. To determine whether VHL plays a role in normal mammary gland...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.