Article
A zebrafish model for VHL and hypoxia signaling.
Methods in cell biology - 1 Jan 2011
van Rooijen Ellen, Santhakumar Kirankumar, Logister Ive, Voest Emile, Schulte-Merker Stefan, Giles Rachel, van Eeden Fredericus
Abstract excerpt
The von Hippel-Lindau (VHL) tumor suppressor gene encodes an adaptor protein that regulates an array of transcription-dependent and -independent cellular and physiological processes. Mutations in this gene cause VHL disease, congenital polycythemia, and several sporadic tumor types. The last 15 years of fundamental and clinical research have helped define the phenotypic spectrum of VHL-associated diseases and...
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