Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Vhl deletion in osteoblasts boosts cellular glycolysis and improves global glucose metabolism.

The Journal of clinical investigation - 1 Mar 2018

Dirckx Naomi, Tower Robert J, Mercken Evi M, Vangoitsenhoven Roman, Moreau-Triby Caroline, Breugelmans Tom, Nefyodova Elena, Cardoen Ruben, Mathieu Chantal, Van der Schueren Bart, Confavreux Cyrille B, Clemens Thomas L, Maes Christa

Abstract excerpt

The skeleton has emerged as an important regulator of systemic glucose homeostasis, with osteocalcin and insulin representing prime mediators of the interplay between bone and energy metabolism. However, genetic evidence indicates that osteoblasts can influence global energy metabolism through additional, as yet unknown, mechanisms. Here, we report that constitutive or postnatally induced deletion of the hypoxia...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow
Share to Bone Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycolysis

Share to Hypoxia

Share to Osteoblasts

Share to Osteocalcin

Share to Von Hippel-Lindau Tumor Suppressor Protein

Share to X-Ray Microtomography

Source

Open in PubMed Open full text

Identifiers

PMID: 29431735
DOI: 10.1172/JCI97794
PMCID: PMC5824856

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Vhl deletion in osteoblasts boosts cellular glycolysis and improves global glucose metabolism.PMID 29431735Read ↗

Mst1/2 Kinases Modulate Glucose Uptake for Osteoblast Differentiation and Bone Formation.Semantic proximity Read ↗

Inactivation of Vhl in osteochondral progenitor cells causes high bone mass phenotype and protects against age-related bone loss in adult mice.Semantic proximity Read ↗

The Warburg effect in osteoporosis: Cellular signaling and epigenetic regulation of energy metabolic events to targeting the osteocalcin for phenotypic alterationSemantic proximity Read ↗

Foxk1 promotes bone formation through inducing aerobic glycolysisSemantic proximity Read ↗

An essential role for IGF2 in cartilage development and glucose metabolism during postnatal long bone growth.Semantic proximity Read ↗

Increased bone density in mice lacking the proton receptor OGR1.Semantic proximity Read ↗

Anoctamin 5 mutation leads to abnormal bone homeostasis of GDD by regulating AMPK-dependent glucose metabolism.Semantic proximity Read ↗

von Hippel Lindau tumor suppressor regulates hepatic glucose metabolism by controlling expression of glucose transporter 2 and glucose 6-phosphatase.Semantic proximity Read ↗

Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone FormationSemantic proximity Read ↗

Diet-Induced Metabolic Dysregulation in Female Mice Causes Osteopenia in Adult OffspringSemantic proximity Read ↗

Deletion of Trp53 and Rb1 in Ctsk‐expressing cells drives osteosarcoma progression by activating glucose metabolism and YAP signalingSemantic proximity Read ↗

Switch from Canonical to Noncanonical Wnt Signaling Mediates High Glucose-Induced AdipogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.