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Article

Evidence from mouse and man for a role of neuregulin 3 in nicotine dependence.

Molecular psychiatry - 1 Jul 2014

Turner J R, Ray R, Lee B, Everett L, Xiang J, Jepson C, Kaestner K H, Lerman C, Blendy J A

Abstract excerpt

Addiction to nicotine and the ability to quit smoking are influenced by genetic factors. We used functional genomic approaches (chromatin immunoprecipitation (ChIP) and whole-genome sequencing) to identify cAMP response element-binding protein (CREB) targets following chronic nicotine administration and withdrawal (WD) in rodents. We found that chronic nicotine and WD differentially modulate CREB binding to the...

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Source

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Identifiers

PMID: 23999525
DOI: 10.1038/mp.2013.104
PMCID: PMC3877725

Genes

NRG3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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